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Phentermine (phenyl–tertiary-butylamine), sold under the brand name Ionamin among others, is a medication used together with diet and
exercise to treat obesity. It is taken by mouth for up to a few weeks. After a few weeks, the beneficial effects no longer occur. It is also
available as a combination of phentermine/topiramate.
Common side effects include a fast heartbeat, high blood pressure, trouble sleeping, dizziness, and restlessness. Serious side effects may
include pulmonary hypertension, valvular heart disease, and abuse. Use is not recommended during pregnancy or breastfeeding. Use is not
recommended together with SSRIs or MAO inhibitors. It works as an appetite suppressant likely as a result of being a CNS
stimulant. Chemically, phentermine is a substituted amphetamine.
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Uses
Phentermine is used with a doctor-approved exercise, behavior change, and reduced-calorie diet program to help you lose weight. It is used
by certain overweight people, such as those who are obese or have weight-related medical problems. Losing weight and keeping it off can
lessen the many health risks that come with obesity, including heart disease, diabetes, high blood pressure, and a shorter life.
It is not known how this medication helps people to lose weight. It may work by decreasing your appetite, increasing the amount of energy
used by your body, or by affecting certain parts of the brain. This medication is an appetite suppressant and belongs to a class of drugs called
sympathomimetic amines.
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- Take this medication by mouth as directed by your doctor, usually once a day, 1 hour before breakfast or 1 to 2 hours after breakfast. If needed, your doctor may adjust your dose to take a small dose up to 3 times a day. Carefully follow your doctor’s instructions. Taking this
medication late in the day may cause trouble sleeping (insomnia).
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- If you are using sustained-release capsules, the dose is usually taken once a day before breakfast or at least 10 to 14 hours before bedtime.
Swallow the medication whole. Do not crush or chew sustained-release capsules. Doing so can release all of the drugs at once, increasing
the risk of side effects.
- If you are using the tablets made to dissolve in the mouth, the dose is usually taken once a day in the morning, with or without food. First,
dry your hands before handling the tablet. Place your dose on top of the tongue until it dissolves, then swallow it with or without water.
The dosage is based on your medical condition and response to therapy. Your doctor will adjust the dose to find the best dose for you. Use
this medication regularly and exactly as prescribed in order to get the most benefit from it. To help you remember, take it at the same
time(s) each day.
- This medication is usually taken for only a few weeks at a time. It should not be taken with other appetite suppressants (see also Drug
Interactions section). The possibility of serious side effects increases with longer use of this medication and the use of this drug along with
certain other diet drugs.
- If you suddenly stop using this medication, you may have withdrawal symptoms (such as depression, severe tiredness). To help prevent
withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used phentermine for a long time or in high
doses. Tell your doctor or pharmacist right away if you have withdrawal.
- Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use
disorder (such as overuse of or addiction to drugs/alcohol). Do not increase your dose, take it more often, or use it for a longer time than
prescribed. Properly stop the medication when so directed.
This medication may stop working well after you have been taking it for a few weeks. Talk with your doctor if this medication stops
working well. Do not increase the dose unless directed by your doctor. Your doctor may direct you to stop taking this medication.
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