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Sibutramine affects chemicals in the brain that affect weight maintenance. Sibutramine is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure. Sibutramine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking sibutramine?

Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life-threatening side effects can occur if you use sibutramine before the MAO inhibitor has cleared from your body. You should not take this medication if you are allergic to sibutramine, or if you have: severe or uncontrolled hypertension (high blood pressure); an eating disorder (anorexia or bulimia);

• a history of coronary artery disease (atherosclerosis);
• a history of heart disease (congestive heart failure, heart rhythm disorder);
• a history of heart attack or stroke; or
• if you are taking stimulant diet pills.

How should I take sibutramine?

• Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

• Sibutramine is usually taken once daily. Follow your doctor’s instructions.
• Your doctor may occasionally change your dose to make sure you get the best results. Sibutramine can be taken with or without food.

• You should lose at least 4 pounds during the first 4 weeks of taking sibutramine and eating a low-calorie diet. Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks.
• Your blood pressure and pulse will need to be checked often. Visit your doctor regularly. Sibutramine should not be taken for longer than 2 years. Store at room temperature away from moisture, heat, and light.
• Do not share sibutramine with another person. Keep the medication in a place where others cannot get to it.

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